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Can We Reverse Hearing Damage?

Loud music at concerts is powerful enough to cause serious hearing damage. Julian explains how it might be possible to reverse this damage.

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Noise-induced hearing loss restored in mice

“Approximately 50 million Americans have hearing loss in at least one ear, with around 26 million Americans aged 20-69 experiencing high-frequency hearing loss as a result of noise exposure.”

Therapy Cures Hearing Loss From Loud Noises

“Scientists restored hearing to mice that were partly deafened by noise. They did it by increasing a key protein in their ears.”

Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma

“Neurotrophin-3 (Ntf3) and brain derived neurotrophic factor (Bdnf) are critical for sensory neuron survival and the establishment of neuronal projections to sensory epithelia in the embryonic inner ear, but their postnatal functions.”

Ribbon synapses

“The ribbon synapse is a type of neuronal synapse characterized by unique mechanisms of multivesicular release and calcium channel positioning that promote rapid neurotransmitter release and signal transmission.”


“Neurotrophin-3, or NT-3, is a neurotrophic factor, in the NGF-family of neurotrophins. It is a protein growth factor that has activity on certain neurons of the peripheral and central nervous system; it helps to support the survival and differentiation of existing neurons, and encourages the growth and differentiation of new neurons and synapses.”

Hearing loss and music

“Adults and children are commonly exposed to loud music. Between ear buds connected to iPods or MP3 players and music concerts, loud music can cause hearing loss.”


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